Minimum quantity lubrication (MQL) in drilling produces aerosol made up of mixture of air and liquid which forms a protective layer to reduce friction and tool wear to increase productivity. This study explains the drilling process performed on titanium alloy Ti-6Al-4V under minimum quantity lubrication (MQL) by hybrid nanofluid Al2O3 - SiO2 blend with a ratio of 90:10 to achieve better drilling performances. The experimental study is performed with drilling control parameters i.e. speed of spindle (N), feed rate (F) and point angle (D) at mixed level with Taguchi L16 orthogonal array to investigate optimum condition yielding minimum thrust force (TF), torque (TQ) and surface roughness (SR). Analysis of Variance (ANOVA) gives significance of control parameters on drilling performances. It was found that speed of spindle is the major significant factor contributing 78.26 %, 70.99 % and 71.53 % of thrust force (TF), torque (TQ) and surface roughness (SR) respectively. Microstructure analysis revealed dynamic transformation resulting in fine grain refinement of drilling under action of hybrid nanofluid of Al2O3+SiO2