Flavonoids are compounds with diverse biological activities and active roles in the prevention of various diseases. Their protective actions are largely due to their anti-oxidant property of scavenging harmful free radicals or because of their ability to bind and interact with various key enzymes and proteins involved in inflammation by modulating their activities. Thus, they help to reduce oxidative stress and inflammatory response and mitigate the damage inflicted during the process to alleviate various pathological conditions including chronic diseases like diabetes mellitus (DM) and cardiovascular diseases (CVDs). Their varied activities like anti-inflammatory, anti-lipidemic and anti-glycemic, vasodilatory, and antihypertensive properties are outcomes of their protective antioxidant nature. Recently, flavonoids have received significant attention from researchers and clinicians. Numerous studies have demonstrated through several lines of evidence to show that flavonoids can control and treat diabetes and diabetes-related complications including CVDs. There is a direct relationship between hyperglycemia and cardiovascular disorders in terms of morbidity and mortality. This review focuses on the signaling mechanisms that contribute to diabetes and its associated disorders and discusses the potential role of flavonoids as a complementary therapy in alleviating disease producing conditions.