In order to raise pharmacokinetics of the drug, stabilising the drug, and concentrating it to a specific spot at a specific rate, microspheres are a unit multiparticulate drug delivery system that can administer drugs for prolonged time period under regulated circumstances. It is the easiest and most efficient way drug delivery method in the microsphere. High blood pressure might harm end organs, as well as accumulated morbidity and mortality as a long-term increase in vital signs. Microspheres containing size of the particle in the range of one to thousand micrometer they are free flowing powders made of artificial polymers or the proteins. Solvent evaporation, chemical synthesis, double emulsion, single emulsion, ionotropic gelation, etc. are a few of the different methods used to create microspheres. In this gift critique, various methods of microsphere preparation and various kinds of antihypertensive medications are discussed along with their mechanisms of action. Hypertension may be a serious challenge worldwide. it's one among the foremost rife conditions seen these days by researchers in each developed an underdeveloped country. relying upon progression of heartbeat and pulse force per unit area it's classified into prehypertension, stage one and a pair of high blood pressure. In regular follow, drug medical aid is being designated from diuretics, β-blockers, atomic number 20 channel blockers and proteolytic enzyme vasoconstrictive system inhibitors either alone or together for each initial and maintenance medical aid.