A simple, sensitive, robust, precise, and efficient RP-HPLC approach for the simultaneous determination of Empagliflozin and Metformin in combination. As per ICH Q2 (R1) guidelines, the final chromatographic conditions were optimized with a mobile phase ratio of (30:70% v/v) in Water containing 0.1% formic acid: Methanol containing 0.1% formic acid at a flow rate of 1 mL/min, column temperature of 35°C, injection volume of 20 µL, Interstil C18 analytical column. Empagliflozin and Metformin reported retention times of 1.73 min and 2.35 min, respectively. Validation of a method was found to be linear in the range of 0.5-1.5 µg/ml for Empagliflozin and 0.63-1.88 µg/mL for Metformin. The % Recovery for Empagliflozin was discovered to be 99.913-100.718%, while for Metformin, it was found to be 99.964-100.188%. The Precision results for both drugs were within the limits while expressed Intraday and Interday. For Empagliflozin, the LOD and LOQ were reported to be 0.106 µg/mL and 0.323 µg/mL, respectively, and for Metformin, 0.129 µg/mL and 0.389 µg/mL. As per ICH Q1A (R2) guidelines, the combination was subjected to acid, base, oxidation, thermal, and photolysis stress conditions.