A simple, novel, economical and precise Liquid chromatography method has been developed and subsequently validated for the simultaneous determination of Ofloxacin and Satranidazole in pure drug and formulations. The best separation was achieved by employing the C18 column and mobile phase consisting of the Ortho-phosphoric acid buffer (pH 3±0.1) and Acetonitrile in the ratio of 70:30.The flow rate was 1.5ml/minute and the effluent was monitored at 278nm. The retention times of Ofloxacin and Satranidazole were found 1.730 and 5.810minute respectively. The linearity plots of Satranidazole and Ofloxacin shows linearity in the concentration ranges of 10.5 to 24 and 7 to 16 µg/ml respectively. The validation of the proposed method has been done statistically and on the basis of the ICH guidelines. The LOD and LOQ of the method were calculated to be 0.59 µg/ml and 1.44 µg/ml of Ofloxacin and Satranidazole respectively. The Precision was estimated by employing repeatability; intra-day and inter-day studies and the results were calculated as %RSD values and were found to be within the acceptable limits. Recovery of both drugs was found to be in the range of 98 and 102 percent, which establishes the accuracy of the method. As the chromatogram for Satranidazole and Ofloxacin in formulation does not show any other peaks except that corresponding to the drugs, it was revealed that common pharmaceuticals excipients used in the formulation were not interfering with the proposed method. So the proposed method is highly suitable for routine analysis of formulations containing of Ofloxacin and Satranidazole