Aim: To evaluate the incidence of malignant transformation of OSMF and to correlate precipitating factors associated with oral submucous fibrosis turning into Oral Squamous Cell Carcinoma. This paper also aims to study the association of OSMF & OSCC. Materials and methods: The study was carried out in the Chennai population reported to the department of Oral Medicine and Radiology,Saveetha Dental College.Data extraction was done through electronic data recording device from the year 2018-2022.A total of 560 patients of OSMF were included in the study.The OSMF cases diagnosed clinically and histopathologically was included in the study.The clinical diagnosis of OSMF was based on difficulty in opening the mouth and associated blanched oral mucosa, with palpable fibrous bands. Other diagnostic features included burning sensation, salivation, tongue protrusion, habits, and associated malignant changes. Study was done on the basis of age group, habit duration, frequency of habit, and type of habit. Simple correlation analysis was performed. Results: Of the 560 cases of OSMF studied, 18% cases were stage I, 27% were stage II, 44% stage III, and 11% stage IV. Based upon age group, group II (20--40 years) showed more prevalence than the others.Based upon gender,incidence of OSMF is more in males when compared to females with 62% and 38% respectively. Conclusion: It is necessary to highlight the malignant potential of OSMF and take all the necessary steps towards prevention of the disease through public awareness rather than waiting for futile effort to treat the same ineffectively. The caption “prevention is better than cure” becomes more relevant for such complicated clinical premalignant conditions.