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ISSN 2063-5346
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In Vitro process optimisation and isolation of antibacterial agents from marine Aspergillus flavus against Klebsiella pneumoniae

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Rutuja Sunil Patankar1 , Nissar Ahmad Reshi2
» doi: 10.48047/ecb/2023.12.si5a.0200

Abstract

The present study is focused on Aspergillus flavus-originated compounds that can be used to treat future infections. Aspergillus flavus CBS 593.65 was isolated from a seawater sample. Agar well diffusion method and bioautography were used to assess the antibacterial potential of broth-fermented chloroform extract of Aspergillus flavus CBS 593.65 against bacterial culture Klebsiella pneumoniae MTCC 432. The compound from A. flavus that had been purified was identified by its chemical name as 2(5H)-Furanone with formula C4H4O2 by using GC-MS and NMR spectroscopy showed an inhibitory activity against Klebsiella pneumoniae MTCC 432. The acquired results lead to the conclusion that this molecule is a strong candidate for antibacterial use, but more research is required before it can be employed as an antibiotic

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