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ISSN 2063-5346
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IN VITRO EVALUATION AND CHARACTERIZATION OF THE NANOPARTICULATE SYSTEM OF NOVEL TAXANE DERIVATIVE

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Dr. Anasuya. Patil, Dr Reshu Tiwari, Mr. Mohit Chadha, Dr. E. Siva Rami Reddy, Mr. Ashok Kumar, Mr. Prashant Sharma, Dr. Mohd Mazhar, Dr. Ujash kumar Shah
» doi: 10.48047/ecb/2023.12.si4.503

Abstract

A brand-new taxane derivative called cabaditaxel (CTX) has been used to treat metastatic prostate cancer that is safe to treat with docetaxel. However, CTX exhibits poor physicochemical properties like low water solubility and disintegration, which are common in chemotherapeutic agents. The multidisciplinary nature of nanoscience and nanotechnology calls for a broad characterization field. In actuality, a more thorough assessment of NPs typically considers both its behavior in vivo and its application security. Regarding their use by the end patient and how they present in vivo, the plan has been detailed and evaluated. Our approach for characterizing nanoparticles in vitro provides an atypical indicator of good strength, market acceptance, and administrative acceptance. The current review includes evaluation of drug moieties, molecular size, surface potential, characterization of strong states, in vitro drug delivery studies, similarity studies, photo safety studies, thermo cycling studies, and stability of reconstitution studies. The advantage of the "atom-driven approach" is emphasized. And weakening strength studies were all performed in the shaped nanoparticle system. Regarding in vivo execution and end-client use, detailing has been demonstrated and explored. Our in-vitro examination of the nanoparticle detailing offers a hazy idea of its extraordinary durability, market viability, and operational viability.

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