The liver is the largest gland of the human body which takes control of both growths as well as regeneration in humans and animals. It is one of the important body organs to maintain homeostasis. One of the biggest reasons for hepatotoxicity isdrug-induced liver injury. The yearly incidence of this is between 10-15per 10000-100000 of the population. The tendency of any substance like any drug or alcohol, any microorganism, or any kind of injury that can lead to any negative or deleterious effect on the liver is known as hepatotoxicity. Hepatotoxicity can be different types including disruption of liver cells and organelles like mitochondria disruption of transport protein, T-cell activation, and hepatocyte apoptosis. Different kinds of hepatic damage can occur due to different kinds of physiological abnormalities including hepatocyte disruption, transport protein disruption, apoptosis of liver cells, and mitochondrial disruption. Chemical induced hepatic damage can also occur these are intrinsic drug reactions and extrinsic drug reactions. Risk factors that can lead to hepatic damage are idiosyncrasy, age, sex, alcohol consumption, and excessive smoking.