Traditionally, the juice and decoction of aerial part and leaves of Lagenaria siceraria was used for cure and management of hepatic disorders in South Asia. There is a scarcity of scientific details to justify the traditional claim for hepatoprotective potential of leaves of L. Siceraria. In the present research work, the hepatoprotective potential was evaluated for methanolic extract of L. siceraria leaves (LSME) against carbon tetrachloride induced hepatotoxicity in albino rats. The levels of hepatic biochemical markers were estimated in treated groups. The treatment with LSME (50 mg/kg) altered back the normal levels of biochemical markers as well as done the significant improvement in the damaged hepatatocytes. The levels of endogenous liver antioxidant enzymes, catalase, superoxide dismutase and glutathione contents were increased significantly. There was also recorded the significant (P<0.001) depletion in serum glutamic-pyruvic transaminase, serum glutamic-oxaloacetic transaminase, Alkaline- phosphatase and total bilirubin in LSME treated group. From these results, it is suggested that methanolic extract of L. siceraria leaves possesses hepatoprotective properties