Introduction: Poor adhesion to medication is a common problem encountered in case of pediatric patients. Besides various reasons, one way to overcome is modification of the form which it appears to pediatrics. Drug incorporation in chocolate may mask the inhibitory feeling of medication in children. The aim of the work is to optimize a chocolate dosage form containing domperidone using response surface methodology. Methods: Drug is complexed with beta cyclodextrin to increase solubility. Chocolate base is prepared using cocoa powder, cocoa butter, milk powder, mannitol and soya lecithin as formulation additives. Prepared medicated chocolates were evaluated for organoleptic properties, drug content and drug release studies. Optimization of the formulation was done using 3 2 full factorial design. Concentration of cocoa butter (X1) and concentration of sweetening agent (X2) were taken as independent variable. The independent variable selected were hardness, melting point and percentage drug release at 15minutes. Polynomial equations and response surface plots were generated for all the dependent variables. Results: Concentration of the coca butter had a negative effect on drug release indicating it as a primary factor to be considered. Concentration of sweetener has positive effect on all the responses. Hardness of the medicated chocolates varies in the range of 1.5 – 3.1 kg/cm2 . Drug from all the chocolate dosage forms was found to release within 45min. Stability study indicates that the formulation is intact with negligible variation in the evaluation parameters. Conclusion: It was observed from the results that medicated chocolates have appreciable organoleptic properties with acceptable drug release.