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ISSN 2063-5346
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Formulation and Evaluation of Nasal Mucoadhesive Microspheres of Mucuna Pruriens

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M. S. Riyazullah1, P.R. Kumar2 , Dr. M. K. Kathiravan3
» doi: 10.48047/ecb/2023.12.5.286

Abstract

Objective: The goal of the experiment was to create and assess mucoadhesive microspheres of Mucuna Pruriens (MP) for the treatment of Parkinsonism by combining the potential benefits of continuous drug delivery with mucoadhesion. Method: In order to create mucoadhesive microspheres, the orifice ionic gelation process was used and prepared nine formulations by varying the percentage of mucoadhesive polymers like sodium alginate, Hydroxypropyl methyl cellulose (HPMC), and methyl cellulose (MC). Evaluations: Prepared microspheres evaluated for the Fourier transform-infrared spectroscopy (FT-IR), SEM, particle size, percentage yield, drug content, entrapment efficiency, percentage moisture content, invitro wash off test, invitro drug release ex-vivo permeation and stability studies.

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