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ISSN 2063-5346
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FORMULATION AND EVALUATION OF HERBAL EFFERVESCENT FLOATING TABLET USING AEGLE MARMELOS FRUIT EXTRACT

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Dr. Kiran C. Mahajan1*, Ms. Shraddha A. Hande2 , Ms. Namrata A. Gholap3 , Ms. Akshada B. Dohale4 , Dr. Shubhrajit Mantry5 , Ms. Pratibha S. Shelke6
» doi: 10.48047/ecb/2023.12.si5a.0166

Abstract

Background: Floating tablets prolong the gastric residence time of drugs, improves bioavailability, and facilitate local drug delivery to the stomach. With this objective, floating tablets containing extract of Aegle marmelos fruit as active ingredient was prepared for the treatment of peptic ulcer. Material and method: Floating tablets of Aegle marmelos were prepared by direct compression method using sodium bicarbonate as effervescent agent, HPMC K4M and HPMC E15 as polymers, Magnesium stearate, Talc, Citric acid and Lactose. The formulations were evaluated for various physical parameters, floating lag time, in-vitro drug release, buoyancy time. Result: The diameter of all formulations was in range 10-11 mm, thickness was in the range 4.02-4.086 mm. The hardness ranged from 3.1-3.3 kg/cm2 , All formulations passed the USP requirements for friability and uniformity of weight. The buoyancy time of all tablet formulations was less than 5min and tablet remained in floating condition throughout the study. Conclusion: The optimized formulation was found to be F8 batch which released 98.13% of drug in 8hr in vitro, while the floating lag time was 35 seconds.

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