Aim of the proposed research was the formulation and evaluation of a compressed coated colon targeted tablet using Budesonide to be used for Crohn’s disease. For this purpose, different polymers like Eudragit L 100, Eudragit S 100, and Ethyl cellulose were used to prevent the contact of core tablet containing Budesonide with 0.1N HCl for 2 hours and in phosphate buffer pH 6.8 for 1 hour. Compression coating of core tablet was done by the powder mixture of polymers with different ratios and different amounts of coating mass and it was concluded that the outer coating for each batch was not stable for 2 hours in 0.1N HCl. Hence, it was decided to prepare the granules of the coating polymer mixture. Different batches were prepared by taking three variables and varying their ratios at three levels (low, medium, high) by using Box Behnken Design. Two batches F10 and F14 were selected as optimized batches as they showed evaluation parameters like hardness, friability, weight variation, disintegration test in 0.1N HCl and in phosphate buffer of pH 6.8 within the standard limits in comparison to other batches. These batches also represented acceptable results for all evaluation tests of tablets and their individual dissolution profiles indicated their suitability to be used as colon targeted drug delivery systems.