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ISSN 2063-5346
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EVALUATION OFSALIVARY HNP1-3PROFILEIN CHILDREN WITH AND WITHOUT EARLY CHILDHOODCARIES USING LIQUID CHROMATOGRAPHY MASS SPECTROMETRY (LCMS)

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Trophimus Gnanabagyan Jayakaran, Shankar Paulindraraj, Nancy Solomon, Bommareddy Sai Charishma, Nimisha Cheruparambil, Hemalatha Ramkumar
» doi: 10.31838/ecb/2023.12.s2.045

Abstract

Aim: To evaluate the salivary HNP1-3profile in children with and without Early Childhood Caries. Materials and Methods:A pilot study with a convenience sample (n=10) were included in the study and were divided into two groups. Group 1 – children with early childhood caries (n=5) and Group 2 – children without early childhood caries (n=5). Saliva samples were collected and salivary HNP1-3 levels were analysedusing Liquid chromatography mass spectrometry. Results:Pool chromatograms showed qualitative differences in HNP1-3 (1744 m/z) profile, noted in peaks 14 and 21, were present in the caries free pool, but absent in the ECC pool. Conclusion:A decrease in the salivary peptides HNP1-3 profile in children with ECCcan help establish specific preventive and treatment protocols.

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