Ulcers can be caused by a number of different things in humans, including stress, long-term use of anti-inflammatory medicines, etc. It is generally acknowledged that ulcer is the outcome of an imbalance between aggressive factors and maintenance of the mucosal integrity through the endogenous defense mechanism, even if the origin of ulcer is unknown in most cases. As a result, scientists are still looking for ways to improve upon existing anti-ulcer medications by assessing the gastroprotective qualities of various medicinal plants. Traditional medicine relies on Spondias mombin L and Calpurnia aurea to cure inflammation and gastrointestinal disorders. The acid-neutralizing capacity (ANC) of the extract was found to be significantly lower at a concentration of 1500 mg compared to 15.7 with standard Aluminium hydroxide + Magnesium hydroxide (500mg) when assessing for anti-ulcer activities using aqueous extract and in-vitro method as the acidneutralizing capacity and H+/K+ - ATPase inhibition activity method. Maximum percentage inhibition of H+/K+-ATPase activity was seen with 100 g of extract compared to 69.56% with regular Omeprazole.