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ISSN 2063-5346
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EVALUATION OF ANTIOXIDANT ACTIVITY: HYPOGLYCEMIC EFFECTS FROM JACKFRUIT (Artocarpusheterophyllus Lam)”

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Cristian Jonny López Manobanda, Héctor Fernando Masabanda Carrillo, Linda Mariuxi Flores Fiallos, María Augusta Guadalupe Alcoser, Evelyn Rocío Ocaña Patarón., Adriana Isabel Rodríguez Basantes
» doi: 10.48047/ecb/2023.12.5.193

Abstract

This research aimed to evaluate the hypoglycemic effect of hydroalcoholic and aqueous extracts of jackfruit leaves (Artocarpus heterophyllus Lam) based on their analysis in rats (Rattus norvegicus). Hydroalcoholic and aqueous extracts were prepared with 125, 250 and 400 ppm concentrations. The hypoglycemic analysis was carried out for 30 days, using 45 male rats, which were divided into 9 groups of 5 rats each, target, negative control, positive control, 3 groups for the hydroalcoholic extract at 125, 250 and 400 ppm, and 3 groups for the aqueous extract at the same concentrations. All 8 groups except the blank were fed a starch-rich diet at a concentration of 2000 ppm (mg/kg) of body weight for 15 days, thus affecting hyperglycemia. After the starch diet, blood glucose was measured on the first, seventh and fifteenth days at 30, 60 and 120-minute intervals. The pharmacological effect was evidenced in hydroalcoholic and aqueous extracts at a concentration of 400 ppm with a p-value ˂ 0.05 through statistical tests comparing their results with the commercially used ones. In conclusion, the antioxidant activity was evaluated: hypoglycemic effects from the hydroalcoholic and aqueous extracts of the leaves of Jackfruit (Artocarpus heterophyllus Lam). Thus, it was recommended to carry out studies onthe identification and chemical purification of the active principle.

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