Inflammation is an immune response and it’s an underlying symptom of many auto-immune diseases and several which are not related with the immunity. Inflammatory mediators like interleukins, TNF- α and prostaglandins are the responsible chemical entities which induces the inflammation. Majorly two Cyclooxygenase isoenzymes are the core reason behind the stimulation of these inflammatory mediators. Current research is carried out on the herbal aspect to treat the condition of the inflammation. P. karka is the drug which contains number of phytoconstituents which are responsible to possess anti-diabetic activity. Useful in the treatment of retinopathy, angiopathy, nephropathy and neuropathy. Current research was carried out on the Albino wistar rats as an experimental subjects for carrageenan induced paw edema model which is the key finding criteria for the current research. Priorly presence of all the chief chemical constituents of the test plant were confirmed by the different identification methods and afterwards the quantitative analysis was carried out by using HPTLC method by using different mobile phases and the detection was carried out by the UV-spectrophotometer. At the end of the study the paw volume was measured and the data was like drug extract shows 0.43±0.001and 0.25±0.004 for the concentration 25 mg/kg and 50 mg/kg respectively. Phenylbutazone was used as a standard anti-inflammatory agent for the current research. All the results of the current study suggest that P. karka possess the antiinflammatory activity and confirmation of the objective can be justify by the carrageenan induced paw edema model.