Male infertility has become the major issue in reproductive biology. Almost 15 percent of Indian couples were affected by infertility and almost 40 - 50 percent will be of male infertility. The changing lifestyles, late marriages, improper food habits, reduced sleep, workplace tension, playing a crucial role in infertility. In developing countries toxic pollutants all over the environment in different ways also increase the intake of heavy metals into the body. The most important heavy metal is lead (Pb) due its usage in everyday life and its biological half life ( 28 to 36 days) in bloodIt is used in ammunition, lead pipes, electric vehicle batteries, used in radiation protecting gears. The widespread disadvantages of lead usage is explored and also there are strict guidelines to reduce its usage. Lead is a strong property of affecting the organism, especially increasing the oxidative stress thereby creating the imbalance in cellular level. The aim of the present research is to find the adverse effects of Lead and its management using the phytocompound Withaferin A, Vitamin A and Selenium.Oxidative stress is created using the lead acetate in groupsII,III & IV animals. The effects of lead toxicity is noted and confirmed in the blood parameters, antioxidant enzymes in testis and oxidative stress markers in testis. Oxidative stress induced animals in groups treated with Withaferin A and Vitamin A + Selenium. Results shown the reversal of the tissue damage in treated animals. Our results concluded the Withaferin A having the property of reversing the tissue damage in testis and its ameliorating effects proven in our present study