Background: Total Hip Arthroplasty (THA) have been recognized as a successful and long-lasting operative measure for the relief of significant morbidity caused by osteonecrosis or avascular necrosis of the hip joint. We conducted this study to determine the efficacy of perioperative periarticular medication injection using locally infiltrative analgesia (LIA) using a cocktail of Ketorolac, Clonidine, Ropivacaine, Adrenaline and distilled water in terms of postoperative pain management in patients undergoing THA.