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ISSN 2063-5346
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DEVELOPMENT AND EVALUATION OF AEGLE MARMELOS POLYSACCHARIDE AS A MATRIX FORMER

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Aishwarya S.Patil1*, Kailas P.Kapse2 , Avinash C.Birajdar3 , Balaji S.Wakure4 , Kiran C. Mahajan
» doi: 10.48047/ecb/2023.12.si5a.0340

Abstract

Examining the formulation of tablets containing sustained-release metoprolol succinate using Aegle marmelose (Bael), a plant belonging to the Rutaceae family, as the matrix-forming polymer, was the overall objective of the study. Excipients are crucial in improving the quality. Results- Aegle marmelose polymers are used in pharmacy similarly to synthetic polymers, which have numerous potential uses as matrix formers in cuttingedge drug delivery systems. Due to the fact that these polysaccharide gums are abundant naturally, biocompatible, biodegradable, and non-immunogenic, as well as the fact that they contribute to economic growth by allowing people to obtain affordable formulations created with components that are easily accessible locally. They may also be adjusted in a variety of ways to obtain the needed properties of components for drug delivery systems, which puts them on par with the currently accessible synthetic additives. The fruits of the Aegle marmelosto are used as a binder in the preparation of metoprolol succinate matrix tablets. The 32 factorial design (F1 to F9) was used to create the metoprolol succinate tablet, and samples from the F6 batch were tested for weight variation, hardness, friability, drug content, drug release research, stability study, solubility study, swelling property, and compatibility with drug excipients. Conclusions- Since there have been no significant changes seen in metoprolol succinate tablets that have been produced and stabilised, aegle marmalose polysaccharide is a more suitable natural binder than synthetic one. Determining the potential of natural polysaccharide was another objective of the study.

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