Background: When a foetus experiences intrauterine stress, it may undergo programmed changes that alter its metabolism and put it at risk for disorders later in life. Objective: The current study sought to determine the relationship between the lipid profile of cord blood and anthropometric data in new-borns. Material and methods: This was prospective observational study of 150 neonates over 24 months from June 2020 to May 2022 in rural tertiary care hospital Karad. The inclusion criteria was neonates with informed consent of their parents and 1 minute Apgar score >7. Whereas we excluded perinatal hypoxia, perinatal sepsis and neonates with congenital anomalies. The neonate’s birth weights were measured and their neonatal ponderal indices (NPI) were calculated. The lipid profile of the neonates' umbilical cord serum was examined, including total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), and low density lipoprotein (LDL). Results: In our study average values of Total cholesterol, LDL, VLDL and TG were significantly higher in SGA compared to AGA and LGA with p<0.05. There was a statistically significant negative correlation between the neonate’s birth weight and TG (P = 0.00, r = -0.374), TC (P = 0.05, r = -0.1630), LDL (P = 0.01, r = -0.210), and VLDL (P <0.001, r= -0.392,) cholesterol level. HDL showed non-significant positive correlation (P = 0.73, r = 0.03). Birth weight increases with decreasing TG, TC, LDL & VLDL with p<0.05, whereas HDL increase with Birth weight increment. Conclusion: The current study has made us conclude that there is correlation between some of the lipid profile parameters and anthropometry at birth of neonates. The babies born with a LBW or with a PI less than 10th percentile or were SGA have exhibited a significantly higher higher LDL, HDL and TC levels as compared to AGA babies