Aim And Objectives: This study evaluated the efficacy of Omega 3, Vitamin A and Vitamin E on the management of Oral Submucous Fibrosis. Materials And Methodology: A non observational study was designed and a total of 21 clinically confirmed adult patients of OSMF were included in the study. Group A was given Omega 3 once daily for 6 weeks. Group B was given Vitamin A once daily for 6 weeks. Group C was given Vitamin E once daily for 6 weeks. Follow up assessment for various symptoms was performed and the results were analyzed. Results: After 6 weeks of follow up, statistically significant improvement among all four clinical parameters i.e. inter-incisal distance (mean improvement in group A = 4.86mm), tongue protrusion (mean improvement in group A = 4.14 mm ) , cheek flexibility (mean improvement in group A= 0.37cm) and reduced burning sensation (VAS in group A = -5.29 score) was observed in group A when compared to group B and Group C. Conclusion: Omega3 is found to be effective in improving Inter-incisal distance, Tongue protrusion, Cheek flexibility and Burning sensation in OSMF Grade 1 and Grade II patients compared to Vitamin A and Vitamin