Numerous short- and long-term issues can arise from endodontic treatment that is completed in a single visit or over the course of several visits. Postoperative discomfort and flare-ups are one of the immediate consequences. The capacity to foresee its occurrence and advise the patient may assist the dentist make judgements about pain management treatments and enable coping mechanisms. Aim To Examine the frequency and severity of postoperative discomfort and flare-ups after pulpectomy in primary molars between single- and various-visit procedures. Additionally, to link postoperative discomfort and flare-ups to the pulp's preoperative condition. Materials and Methods The study comprised 80 primary molars that had pulpectomy indications and split them into two groups. Preoperative pulp vitality status was reported for the tooth that underwent treatment. The entire pulpectomy process was carried out according to protocol. On the same visit as the pulpectomy for Group 1's teeth, the teeth were obturated. In the subsequent appointment, teeth in Group 2 (multiple visit pulpectomy) were obturated. After 24 hours, 7 days, and 1 month, the postoperative discomfort, flare-ups, and medication use were recorded. Results A 24 hour recall revealed postoperative pain in four individuals in both groups (10%; p=0.74). Each group experienced one flare-up (2.5%; p=0.67). At the seventh day and one month after recall, none of the patients complained of pain. Three important teeth (6.9%) and five non-vital teeth (13.5%) both reported post-operative pain. Statistically speaking, it was insignificant (p=0.53). Conclusion There was a relatively low incidence of postoperative discomfort from the standpoint of our investigation. Within 24 hours of treatment, the majority of patients in both groups reported no pain or very little pain. The incidence of postoperative discomfort did not differ between the single- and multi-visit therapy strategies. Pulp vitality and the likelihood of postoperative discomfort have no discernible relationship.