Caudal Regression Syndrome (CRS) is a spectrum of congenital malformations that consist of anomalies of the urinary and genital systems, the rectum, the lower limbs, and the lumbo-sacral spine. Though the exact etiology leading to caudal regression syndrome is still unknown, it has been hypothesised that genetic influence as well as maternal pathologic factor like diabetes plays an important role. The severity of CRS depends on function of the residual spinal cord. Patients may present with mild to severe neurological involvement with or without visceral anomaly. Here, we report a case of caudal regression syndrome with associated spinal and vertebral abnormalities in an 20 year old male who presented with complaints of lower limb twitching movement and associated left club foot.