Background: Prevalence data of Interstitial lung abnormalities (ILAs) in asymptomatic smokers are rising. However, there are insufficient data about the association between ILAs and Chronic obstructive pulmonary disease (COPD). Objective: this study was planned to detect the prevalence of ILAs in a cohort of smokers to know the effect of the presence or absence of COPD on the development of ILAs. Methods: This study examined 102 men smokers. The studied participants were divided according to the presence or absence of COPD into a group of COPD patients and a group of non-COPD smokers. A non-contrast examination with CT scanner was used to detect ILAs. Results: 49.1% of COPD patients had definite ILAs and 14.5% had equivocal ILAs. However, 8.5% of non-COPD smokers had definite ILAs and 12.8% had equivocal ILAs. All reported ILAs in non-COPD smokers were non fibrotic. Nevertheless, 40% of reported ILAs in COPD group were fibrotic. The presence of ILAs in COPD patients in this study not significantly associated with age, COPD group and severity of airflow limitation. Conclusion: ILAs are more frequent among COPD smokers than non-COPD smokers. CT might give important diagnostic data about ILAs especially in absence of symptoms or pulmonary function abnormalities.