The study examined the efficacy of ethanol extracts obtained from Vitex scabra and Syzygium gratum in terms of their antioxidant and antimicrobial activities. The Folin-Ciocalteu reaction was utilized to determine the total phenolic content of the extracts. The antioxidant capacity of the extracts was measured using the DPPH and ABTS assays.The findings indicated that S. gratum extract had higher antioxidant activity than V. scabra extract as demonstrated by both DPPH and ABTS assays. The total phenolic content of the extracts had a significant correlation with DPPH and ABTS assays, with S. gratum extract possessing higher amounts of phenolic compounds than V. scabra extract. The antimicrobial activity of the extracts was measured using the broth dilution method against Candida albicans, Clostridium butyricum, and Pseudomonas aeruginosa. The V. scabra extract showed antimicrobial activity against Clostridium butyricum with a MIC value of 1.37 mg/ml. These findings suggest that both plants could serve as natural sources of antioxidant and antimicrobial agents