The aim of the present study is to comparatively evaluate the antimicrobial effect of the silver nanoparticles, AgNPs, that were synthesized biogenically from the bacterial isolate K. pneumoniae (BNP) and Neem leaf extract (NLNP), for the best possible application as an alternative mode of treatment. The AgNPs thus formed were divided into 2 categories out which one part was capped with the Polyethylene glycol or PEG while the other part remained uncapped. These AgNPs were further characterized by TEM, UV-Vis Spectroscopy. FTIR, DLS and XRD in order to assess their molecular properties. Topographical assessment of size of these AgNPs by TEM demonstrated their size to be 19 nm for BNP and 24 nm for NLNP. These AgNPs were then tested for their antifungal activity against the azole resistant C. albicans that were obtained from the Chronic Periodontitis patients. Antimicrobial sensitivity testing of the isolated C. albicans demonstrated them to resist Fluconazole, Itraconazole, Clotrimazole and Ketoconazole group of antifungal antibiotics. Strong antimicrobial activity of BNP and NLNP against this pathogen was noted in the form of large zones of inhibition measuring 18.7 mm and 20.1 mm for NLNP and BNP, respectively. PEG coated NLNP on the other hand displayed 18 mm while PEG coated BNP displayed 18.2 mm of zone. Based on the study conducted it was observed that uncoated BNP had a strong antifungal activity on the azole resistant C. albicans as compared to the other AgNPs. The data thus obtained from the present study suggests that BNPs can be used as an alternative approach for the treatment of infections caused by Azole resistant C. albicans.