Objective: to evaluate the rational use of beta-lactam antibiotics in Hospital Type 2, observing that the management of beta-lactam antibiotics is vital. Methodology: the study was carried out in two phases. In the first phase, information was collected from the hospital database, where 892 clinical histories were identified; once inclusion and exclusion criteria were considered, 93 accessible clinical histories were obtained. The data were tabulated and statistically processed in the second phase using the IBM SPSS Statistics 26 program.