Dhatura is a part of the Solanaceae family and belongs to the genus Datura, which is thought to have both poisonous and therapeutic characteristics due to the diverse variety of bioactive ingredients. The Dhatura plant’s common names are thorns apple and Jimson Weed, mad apple, and moonflower. Plants are used to cure a variety of human diseases. Alkaloids, sugars, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic substances were identified in the preliminary phytochemical analysis of the Datura plant extract. Additionally, it contains dangerous tropane alkaloids like hyoscyamine, atropine, and scopolamine. Even while some research on D. stramonium has suggested possible pharmacological effects, the toxicity of the organism is still mostly unknown. Additionally, toxic symptoms have been brought on by the regular misuse of D. stramonium for recreational purposes. Therefore, its use's harmful effects and potential hazards must be understood. This paper aims to provide an overview of the plant Datura's, phytochemical makeup, pharmacological properties, toxicological properties, and treatment of Dhatura poisoning.