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ISSN 2063-5346
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AN OVERVIEW ON GLYMPHATIC SYSTEM

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Kapil Kalra, Himani Dumka , Jyoti Maithani Kalra, Kashif Hussain , Shabeen Parveen , Urvashi Negi
» doi: 10.31838/ecb/2023.12.si5.079

Abstract

The glymphatic system is a recently recognized macroscopic waste clearance system that utilizes of a unique network of perivascular channels produced by astrocytes to facilitate effective removal of soluble proteins and metabolites from the brain. A complex and well-organized clearance system is vital to prevent the accumulation of byproducts and ensure optimal function. However, there hasn't been much research on this subject up to this point. The glymphatic system may help the brain distribute non-waste substances including glucose, lipids, amino acids, and neurotransmitters involved in volume transmission in addition to helping with waste disposal. The glymphatic system, also known as perivascular pathway, is a recently described glial dependent network that is responsible for the clearance of metabolites from the central nervous system (CNS), playing a role equivalent to the one played by the lymphatic vessels present in other organs. Maximizing efficiency of mass transport system, support ageing of healthy brain, and maybe halt neurological disorder, this review will merge presented information on glymphatic clearance, sleep, Alzheimer's disease, Parkinsons disease, Multiple sclerosis and lifestyle choices. This study comes under following conclusions: 1. In Alzheimer diseases’s pathology glymphatic clearance plays a significant role 2. During the sleeping maximum clearance of waste product occur from the brain. 3. Dementias are associated with sleep disruption and an age-related decline in AQP4 polarisation; and 4. Glymphatic clearance is modulated by lifestyle factors like sleeping posture, consumption of alcohol, physical workout, and omega-3 dietary supplements. Research has shown that the glymphatic pathway is crucial for maintaining protein homeostasis and that problems with this system may contribute to the emergence of neurodegenerative diseases like Alzheimer's disease

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