Stress is the arousal of the mind and body in response to demands made upon them. During the Covid-19 pandemic, healthcare workers faced different stressors of varying degrees, with work-related stress being one. This leads to the workers facing health and/or emotional issues. Determining the extent of stress-related health problems at work is not an easy task. The statement of the study is to assess the level of stress among staff nurses during Covid-19 pandemic at selected hospitals in Chennai, Tamil Nadu. The objective of the study is to assess the level of stress among staff nurses, to associate the level of stress among staff nurses with demographic variables, to create awareness of the effect of stress and coping strategies among staff nurses. A quantitative approach was adopted for the study. The research design used in this study is descriptive design. The study was conducted in selected hospitalsin Chennai. The samplesize of the study was 60, selected by using the probability random sampling technique. A semi-structured interview schedule was used to assess the level of stress among staff nurses. A semi-structured questionnaire was administered to staff nurses who were posted in the Covid-19 ward. Staff nurses were taught about the effect of stress and coping strategies.The result showed that 50% of the sample had moderate stress, 35% of the samples had severe stress and 15% had mild stress.