The health care industries have experienced profound changes during the past several decades. Nursing as a health care profession and a major component of the health care delivery system is significantly affected by shifts in the healthcare industry, especially in psychiatric nursing practice. The psychiatric nurse has to look after all other aspects of health care. Thus, they undergo tremendous stress in their occupational life as well as their personal life. The current study was aimed to assess the level of occupational stress and Job satisfaction among staff nurses working in psychiatric hospitals. Formal Ethics committee approval was taken and permission was obtained from selected psychiatric hospitals. 50 staff nurses were selected through non probability purposive sampling technique. Stress assessment scale & Job satisfaction scale was used to get the responses from the respondents. The data collection tool was validated by nursing experts and reliability of the tool was obtained. 78% of the nurses were in mild stress and 56% of the nurses were satisfied with their job. The identified stress needs to be explored more and relevant stress buster’s activities needs to be implemented time to time to keep the staff nurses mentally healthy to cater the clients.