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ISSN 2063-5346
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A study on role of plasma fibrinogen level as a risk factor for development of various complications in type 2 diabetes patients

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Dr. Sunil Kumar, Dr. Het V Patel, Dr. Aarsh Shah, Dr. Kathrotiya Vishalkumar R
» doi: 10.31838/ecb/2023.12.si4.166

Abstract

Diabetes mellitus (DM) represents a collection of common metabolic disorders, with main focus being the glycemic control. Increased level of fibrinogen is observed in diabetics and largely reflects elevated hepatic production through the actions of inflammatory cytokines and insulin. In this study, attempt was made to infer the relation of fibrinogen level with various risk factors like glycemic control, smoking, hypertension, obesity, dyslipidemia and different microvascular and macrovascular complications among diabetes mellitus patients. A cross sectional observational study was conducted at medicine department of Dhiraj Hospital, Vadodara. Total of 114 newly diagnosed or known case of the diabetes mellitus patients presenting at outpatient department of the internal medicine department were included during study period i.e. one and half years for the study. The level of fibrinogen as well as presence of various risk factors like smoking, hypertension, obesity, dyslipidemia and different microvascular and macrovascular complications were assessed. Ethical permission taken form the institutional ethical committee. Informed consent was taken from each subject prior to inclusion in the study. The average age of the patients was 55.1 years with male preponderance (62.3%).Smoking, overweight/ obesity, hypertension, uncontrolled diabetes and dyslipidaemia was reported in 54.4%, 30.7%, 41.2%, 28.1% and 60.5% respectively. Microvascular complication like retinopathy, nephropathy and neuropathy was reported in 34.2%, 40.4% and 21.1% patients respectively.Macrovascular complications like coronary artery disease and stroke was reported in 20.2% and 16.7% patients respectively. The mean fibrinogen level was and 441.9±31.1 mg/dl among study participants. Average level of fibrinogen found higher among patients with microvascular as well as macrovascular complication.

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