Stress is very closely related to physical health and mental health. There are common factors like social support and personality that affect them. Moreover, they are also interlinked as well. In this review, the interrelationship between these factors, stress and health is explored. Overall, the review will highlight the importance of social support and personality to thrive and live a disease-free life for an individual. This study will provide a thorough idea of relationship of these factors with health.