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ISSN 2063-5346
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A REVIEW OF COUMARIN DERIVATIVES HAVING DIFFERENT BIOLOGICAL ACTIVITIES

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Apeksha Singh1*, Deepti Dwivedi2, Bushra Fatima3, Ahtesham Ahmad4, Ashwani Gond5, Sadhana Rajvanshi6, Sadaf Fatima7
ยป doi: 10.48047/ecb/2023.12.5.135

Abstract

Coumarin (2H-Chromen-2-one) is a heterocyclic compound having molecular formula C9H6O2 and contains oxygen in its structure. Coumarin belongs to the lactones family having a benzopyrene system. Many coumarinnucleiplay an important role in medicinal chemistry to synthesize a series of various biologicalactive derivatives as anti-inflammatory, antipyretic, antioxidant, bronchodilator, vasodilator, antiamoebic, antibacterial, and antifungal activities. Apart from this, coumarinsalso act as lipid-lowering agents having mild triglyceride-lowering activity.Many chemical reactions have been established that can be used to synthesize coumarinslike the Knoevenagel condensation reaction, Perkin, Pechmann reaction, and Reformat sky and Wittig reactions. All the coumarin derivatives are mentioned in the article,these derivatives of coumarin are tested for various pharmacological activities. The main motive of this review article isto describe their pharmacological action and activities against different types of bacteria by using different types of models(invitro assay, in vivo assay,etc). This review article aims to review the various biological activities of coumarin derivatives.

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