Diabetic foot ulcer (DFU) is a severe and common consequence of diabetes mellitus. The present study was conducted to assess the effect of collagen dressing in diabetic foot ulcer patients. Materials & Methods:70 diabetic foot ulcer (DFU) patients of both genders were divided into 2 groups of 35 each. In group I, patients were treated with a 100% porcine type I collagen sheet covered by a polyurethane foam dressing and patients in the group II were treated with only polyurethane foam dressing. DFU size was measured using a digital planimetry wound measurement system. Results: In group I, males were 20 and females were 15 and in group II, males were 17 and females were 18. Duration was 18.5weeks in group I and 13.2weeks in group II. Side was right in 16 and 18 and left in 19 and 17 in group I and II respectively. Location was interphalangeal area in 1 and 12, sole in 14 and 10, heel in 11 and 8, Toe in 8 and 3 and Malleolus in 1 and 2. Wagner grade was grade I in 31 and 33 and grade II in 5 and 2 in group I and II respectively. Adverse events reported were infective events in 1 and 1, pain in 2 and 2 and maceration in 1 and 2 in group I and II respectively. Themean size of ulcer initially in group I was 4.82 cm2 and in group II was 4.35 cm2and at 3 months follow up was 0.56 cm2 in group I and 1.64 cm2in group II.