E-ISSN 2063-5346
 

Research Article 


THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan.

Abstract
Background: Chronic renal failure (CRF) frequently involves anemia, which is linked to a lower standard of living as
well as a higher risk to morbidity and mortality. The current study's objectives were to examine early CKD prediction and
diagnostic, estimate a few biochemical indicators, and determine the relationship between Haemoglobin concentration, renal
function testing, and GDF. Materials and methods: A total of 60 cases, including 20 controls and 40 patients with Chronic renal
failure (CRF), have been examined in this study. This age group of the patients was 25 to 65. Age, Body Mass (BMI), Bones
Hematological Parameter, and Kidney Function Test (urea and creatinine) are calculated for the study patients. The research also
measured total GDF levels inside the CKD patient and control groups. Result: When patients with CKD are compared to controls,
the study's findings show a significant decline in hematological characteristics (Hb, RBC, and GFR). In contrast to controls,
individuals in CKD had statistically significant increases (p 0.05) in their serum concentrations of urea and creatinine. When
compared to the healthy control group, the results revealed a significant rise in GDF in CKD patients. This biomarker also exhibited
a positive correlation with BMI and a negative correlation with Hb and GFR in CKD patients. Conclusions: Our investigation came
to the conclusion that there was strong evidence linking CKD and anemia. Increased circulating GDF-15 concentrations were
associated with higher mortality in adults with CKD. A higher rate of heart failure was likewise associated with elevated GDF-15
levels. The mechanisms linking these circulating biomarkers to cardiovascular disease in CKD patients require further
investigation. This GDF is adversely regulated by hemoglobin. Therefore, there is a link among GDF15 concentrations as well as
the likelihood of anemia in CKD patients. In CKD patients, there is a favorable connection between GDF and BMI. Therefore, a
rise in BMI is a significant risk factor for the development of chronic renal disease. As there is a strong clinical correlation among
GDF with renal problems, In CKD patients, GDF and GFR are negatively correlated. Early renal illness causes an increase in GDF,
and anemia caused by a drop in Hb causes anemia. The GDF is a good biomarker for predicting kidney disease and anemia at the
outset of the disease, as a result of what we have suggested.

Key words: CKD, Chronic kidney disease, CRF, Chronic renal failure, BMI, Growth differentiation factor 15, GDF


 
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How to Cite this Article
Pubmed Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . ECB. 2022; 11(5): 10-16. doi:10.31838/ecb/2022.11.05.002


Web Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . https://www.eurchembull.com/?mno=96691 [Access: September 25, 2022]. doi:10.31838/ecb/2022.11.05.002


AMA (American Medical Association) Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . ECB. 2022; 11(5): 10-16. doi:10.31838/ecb/2022.11.05.002



Vancouver/ICMJE Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . ECB. (2022), [cited September 25, 2022]; 11(5): 10-16. doi:10.31838/ecb/2022.11.05.002



Harvard Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan (2022) THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . ECB, 11 (5), 10-16. doi:10.31838/ecb/2022.11.05.002



Turabian Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. 2022. THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . European Chemical Bulletin, 11 (5), 10-16. doi:10.31838/ecb/2022.11.05.002



Chicago Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. "THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE ." European Chemical Bulletin 11 (2022), 10-16. doi:10.31838/ecb/2022.11.05.002



MLA (The Modern Language Association) Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan. "THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE ." European Chemical Bulletin 11.5 (2022), 10-16. Print. doi:10.31838/ecb/2022.11.05.002



APA (American Psychological Association) Style

Maryam Kadhim Al-Shemery, Rusul Ali AL-Masaoodi, Fadhel Y Khudheyer, Saif M. Hassan (2022) THE CONCENTRATION OF GDF-15 IS RELATED WITH THE INCIDENCE OF HEART FAILURE . European Chemical Bulletin, 11 (5), 10-16. doi:10.31838/ecb/2022.11.05.002