E-ISSN 2063-5346
 

Research Article 


A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati.

Abstract
Patients with diabetes mellitus often experience adverse complications, one of which is diabetic foot ulcers. Administering synthetic chemical drugs and physical treatment for wound healing and tissue regeneration deficiency in hyperglycemia is considered less effective and incurs high cost if long-term treatment is given. Ineffective therapy for diabetic foot ulcers carries the high risk of amputation and death. The development of plant-derived drugs is potential to discover effective, affordable, and safe therapy. Centella asiatica L. (C. asiatica) has wound-healing activities on the skin supported by its antibacterial, anti-inflammatory, antidiabetic, and antioxidant properties. Some of these pharmacological activities are expected to synergize in the healing process of diabetic ulcers. This review aims to reveal the supporting pharmacological activities of C. asiatica in wound healing which can be the basis for developing diabetic foot ulcer therapy. This study was conducted as a literature review through searches using the keywords "Centella asiatica", "wound healing", "antidiabetic activity", "antibacterial activity", and "antioxidant activity" from various journal articles in NCBI, PubMed, and other journal sources. The results show that C. asiatica has the potential to be developed for diabetic foot ulcer therapy with its supporting pharmacological activities, including the antidiabetic, anti-inflammatory, antioxidant, and antibacterial properties, which will improve its effectiveness in the wound-healing process.

Key words: Centella asiatica L, diabetic ulcer, wound healing


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Lia Nurkhasanah
Articles by Arba Pramundita Ramadani
Articles by Farida Hayati
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. ECB. 2022; 11(12): 07-21. doi:10.31838/ecb/2022.11.12.002


Web Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. https://www.eurchembull.com/?mno=141748 [Access: January 26, 2023]. doi:10.31838/ecb/2022.11.12.002


AMA (American Medical Association) Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. ECB. 2022; 11(12): 07-21. doi:10.31838/ecb/2022.11.12.002



Vancouver/ICMJE Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. ECB. (2022), [cited January 26, 2023]; 11(12): 07-21. doi:10.31838/ecb/2022.11.12.002



Harvard Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati (2022) A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. ECB, 11 (12), 07-21. doi:10.31838/ecb/2022.11.12.002



Turabian Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. 2022. A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. European Chemical Bulletin, 11 (12), 07-21. doi:10.31838/ecb/2022.11.12.002



Chicago Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. "A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY." European Chemical Bulletin 11 (2022), 07-21. doi:10.31838/ecb/2022.11.12.002



MLA (The Modern Language Association) Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati. "A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY." European Chemical Bulletin 11.12 (2022), 07-21. Print. doi:10.31838/ecb/2022.11.12.002



APA (American Psychological Association) Style

Lia Nurkhasanah, Arba Pramundita Ramadani, Farida Hayati (2022) A REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF CENTELLA ASIATICA L. : THE POTENTIAL FOR DIABETIC FOOT ULCER THERAPY. European Chemical Bulletin, 11 (12), 07-21. doi:10.31838/ecb/2022.11.12.002