E-ISSN 2063-5346
 

Research Article 


THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES

Challamalla Pavani, Dr.V. Jayashree.

Abstract
This study's focus is on the simultaneous assessment of Rilpivirine and Cabotegravir using RP-HPLC in bulk and
tablet dosage form. Materials and methods: The separation was carried out on a Zorbax SB C18 (4.6 x 150mm, 5 m) analytical
column using a mobile phase of 40% Water (0.1 percent Formic Acid): 60% Acetonitrile. Using a UV detector, the eluents were
found at 248.0 nm. Results: Under optimal circumstances, Rilpivirine and Cabotegravir were separated at 2.084 and 3.2mins,
respectively. The detection limit for Rilpivirine was 1.02µg/mL, while the detection limit for Cabotegravir was 3.30µg/mL.
Cabotegravir had a percentage mean recovery of 100.02 percent, but Rilpivirine had a recovery rate of 100.72 percent.
Conclusion: The percentage of degradation was determined to be extremely low in each stressful environment. It was found that
optimized conditions were incredibly ideal for simultaneously determining all of them in both marketing dose form and bulk
form

Key words: Cabotegravir, Rilpivirine, method development, validation, and RP-HPLC.


 
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Pubmed Style

Challamalla Pavani, Dr.V. Jayashree. THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . ECB. 2022; 11(5): 64-70. doi:10.31838/ecb/2022.11.05.010


Web Style

Challamalla Pavani, Dr.V. Jayashree. THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . https://www.eurchembull.com/?mno=105236 [Access: September 25, 2022]. doi:10.31838/ecb/2022.11.05.010


AMA (American Medical Association) Style

Challamalla Pavani, Dr.V. Jayashree. THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . ECB. 2022; 11(5): 64-70. doi:10.31838/ecb/2022.11.05.010



Vancouver/ICMJE Style

Challamalla Pavani, Dr.V. Jayashree. THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . ECB. (2022), [cited September 25, 2022]; 11(5): 64-70. doi:10.31838/ecb/2022.11.05.010



Harvard Style

Challamalla Pavani, Dr.V. Jayashree (2022) THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . ECB, 11 (5), 64-70. doi:10.31838/ecb/2022.11.05.010



Turabian Style

Challamalla Pavani, Dr.V. Jayashree. 2022. THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . European Chemical Bulletin, 11 (5), 64-70. doi:10.31838/ecb/2022.11.05.010



Chicago Style

Challamalla Pavani, Dr.V. Jayashree. "THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES ." European Chemical Bulletin 11 (2022), 64-70. doi:10.31838/ecb/2022.11.05.010



MLA (The Modern Language Association) Style

Challamalla Pavani, Dr.V. Jayashree. "THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES ." European Chemical Bulletin 11.5 (2022), 64-70. Print. doi:10.31838/ecb/2022.11.05.010



APA (American Psychological Association) Style

Challamalla Pavani, Dr.V. Jayashree (2022) THE DEVELOPMENT OF A NOVEL STABILITYINDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS EVALUATION OF RILPIVIRINE AND CABOTEGRAVIR IN PURE API FORM AND TABLET DOSAGE IN ACCORDANCE WITH ICH GUIDELINES . European Chemical Bulletin, 11 (5), 64-70. doi:10.31838/ecb/2022.11.05.010