E-ISSN 2063-5346
 

Original Article 


IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.

Jasmin Sheela. M, Sharulatha. V.

Abstract
The widespread use of conventional antibiotics has contributed to the spread of several resistant harmful bacterial
species. Therefore, we aimed to discover the new sulfathiazole derivatives against methicillin-resistant Staphylococcus aureus
(MRSA). In this study, 70 new sulfathiazole derivatives were designed based on the synthetic possibility. From the 70 designed
molecules, we screened potent 5 active molecules (Mol-1, Mol-5, Mol-6, Mol-10, Mol-13) based on the molecular docking
studies on MRSA receptors and ADMET analysis. According to this work, the selected five molecules show good binding
affinity with the MRSA receptor and drug-like properties. Moreover, these selected compounds were synthesized and
determined their biological activity against MRSA and wild-type S. aureus. The in-vitro results revealed that the virtually
screened and synthesized compounds displayed very good activity against MRSA and wild-type S. aureus. These findings
showed us that Mol-1, Mol-5, Mol-6, Mol-10, and Mol-13 could be lead compounds to discover new antibacterial candidates
against MRSA.

Key words: MRSA, sulfathiazole, Docking, ADMET, Virtual screening


 
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Pubmed Style

Jasmin Sheela. M, Sharulatha. V. IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. ECB. 2022; 11(6): 90-96. doi:10.31838/ecb/2022.11.06.013


Web Style

Jasmin Sheela. M, Sharulatha. V. IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. https://www.eurchembull.com/?mno=112773 [Access: November 29, 2022]. doi:10.31838/ecb/2022.11.06.013


AMA (American Medical Association) Style

Jasmin Sheela. M, Sharulatha. V. IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. ECB. 2022; 11(6): 90-96. doi:10.31838/ecb/2022.11.06.013



Vancouver/ICMJE Style

Jasmin Sheela. M, Sharulatha. V. IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. ECB. (2022), [cited November 29, 2022]; 11(6): 90-96. doi:10.31838/ecb/2022.11.06.013



Harvard Style

Jasmin Sheela. M, Sharulatha. V (2022) IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. ECB, 11 (6), 90-96. doi:10.31838/ecb/2022.11.06.013



Turabian Style

Jasmin Sheela. M, Sharulatha. V. 2022. IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. European Chemical Bulletin, 11 (6), 90-96. doi:10.31838/ecb/2022.11.06.013



Chicago Style

Jasmin Sheela. M, Sharulatha. V. "IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.." European Chemical Bulletin 11 (2022), 90-96. doi:10.31838/ecb/2022.11.06.013



MLA (The Modern Language Association) Style

Jasmin Sheela. M, Sharulatha. V. "IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.." European Chemical Bulletin 11.6 (2022), 90-96. Print. doi:10.31838/ecb/2022.11.06.013



APA (American Psychological Association) Style

Jasmin Sheela. M, Sharulatha. V (2022) IN-SILICO AND IN-VITRO ANALYSIS OF THE NEW SULFATHIAZOLE DERIVATIVES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.. European Chemical Bulletin, 11 (6), 90-96. doi:10.31838/ecb/2022.11.06.013