E-ISSN 2063-5346
 

Original Research 


Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm

Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi, Asriullah Jabbar, Erika Nandini.

Abstract
The emerging resistance to anti-fungal agents encourage the exploration of new and effective natural product showing anti-fungal activity to significantly impact the treatment and the management of biofilm associated fungal infections. In nature, most of microbes live in form of biofilms, and up to 80% of microbial infections on human body are biofilms associated. This research aimed at finding out antibiofilm activity of Bajakah tampala extract against Candida albicans. The inhibition and eradication activities toward C. albicans biofilm were tested using microtiter broth method by measuring the minimum value of biofilm inhibition concentration (MBIC50) and minimum biofilm value eradication concentration (MBEC50). The C. albicans biofilm structure in front of and absence of the extracts was analysed using SEM. At concentration of 1% w/v Bajakah tampala extract showed activity against C. albicans mid-phase biofilm formation and maturation phase (77.00% ± 0.01, 70.31% ± 0.01) and breakdown the established biofilms as much as 65.21% ± 0.01. The biofilm architecture analysis by SEM provided evidence that Bajakah tampala ethanol extract disturbed the extracellular polymeric substance (EPS) matrix of the C. albicans biofilm. The result obtained clearly indicate that Bajakah tampala exthanol extract can developed as a new antibiofilm candidate for the treatment of C. albicans biofilm infection.

Key words: Bajakah tampala, biofilm, C. albicans, infection, antibiofilm


 
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How to Cite this Article
Pubmed Style

Hamzah H, Pratiwi SUT, Jabbar A, Nandini E. Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. ECB. 2022; 11(5): 59-63. doi:10.31838/ecb/2022.11.05.009


Web Style

Hamzah H, Pratiwi SUT, Jabbar A, Nandini E. Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. https://www.eurchembull.com/?mno=71286 [Access: September 25, 2022]. doi:10.31838/ecb/2022.11.05.009


AMA (American Medical Association) Style

Hamzah H, Pratiwi SUT, Jabbar A, Nandini E. Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. ECB. 2022; 11(5): 59-63. doi:10.31838/ecb/2022.11.05.009



Vancouver/ICMJE Style

Hamzah H, Pratiwi SUT, Jabbar A, Nandini E. Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. ECB. (2022), [cited September 25, 2022]; 11(5): 59-63. doi:10.31838/ecb/2022.11.05.009



Harvard Style

Hamzah, H., Pratiwi, . S. U. T., Jabbar, . A. & Nandini, . E. (2022) Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. ECB, 11 (5), 59-63. doi:10.31838/ecb/2022.11.05.009



Turabian Style

Hamzah, Hasyrul, Sylvia Utami Tunjung Pratiwi, Asriullah Jabbar, and Erika Nandini. 2022. Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. European Chemical Bulletin, 11 (5), 59-63. doi:10.31838/ecb/2022.11.05.009



Chicago Style

Hamzah, Hasyrul, Sylvia Utami Tunjung Pratiwi, Asriullah Jabbar, and Erika Nandini. "Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm." European Chemical Bulletin 11 (2022), 59-63. doi:10.31838/ecb/2022.11.05.009



MLA (The Modern Language Association) Style

Hamzah, Hasyrul, Sylvia Utami Tunjung Pratiwi, Asriullah Jabbar, and Erika Nandini. "Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm." European Chemical Bulletin 11.5 (2022), 59-63. Print. doi:10.31838/ecb/2022.11.05.009



APA (American Psychological Association) Style

Hamzah, H., Pratiwi, . S. U. T., Jabbar, . A. & Nandini, . E. (2022) Efficacy of Bajakah Tampala Ethanol Extract, A Typical Plant of Kalimantan Island (Borneo), Against Candida albicans Biofilm. European Chemical Bulletin, 11 (5), 59-63. doi:10.31838/ecb/2022.11.05.009