E-ISSN 2063-5346
 

Research Article 


Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats

hamzah H kzar, Zahraa H Kadhim, Areej GH Al-Charak.

Abstract
Abstract
In this study, we examined the berberine-chitosan nanoparticles (BCNP) action as a natural polymer used to enhance liver and kidney damage induced by phenylhydrazine in male rats. Healthy 20 male Sprague-Dawley rats weighed 150 - 200 g were used in this study and the animals were randomly divided into four groups, G1: (CON), G2: chitosan (CHS), G3: berberine (BER), and G4: berberine-chitosan NPs (BCNPs). Serum ALT, AST, TP, and TB for assessment of liver damage, and creatinine (CRI) and urea (UR) were measured to investigate kidney damage. The administration of experimental rats with BCNPs done by the current study BCNPs with the dose of 0.5 mg/Kg B.W. will be given protection from hepatotoxic and kidney damage action of phenylhydrazine. Liver sections revealed moderate improvement of the hepatic artery, portal vein, and bile duct and reorganization of hepatic cords. Kidney sections illustrated also moderate improvement of tubular necrosis. In conclusion, the usage of BCNPs as a natural polymer with moderated modifications has greatly improved the curative effect of pure BER and CHS to protect the liver and kidneys against toxicity induced by phenylhydrazine that may be by a reduction in lipid peroxidation and enhancement of the main markers of liver and kidney.

Key words: Liver and kidney damage, Berberine, Chitosan, drug delivery,


 
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How to Cite this Article
Pubmed Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB. 2022; 11(5): 31-37. doi:10.31838/ecb/2022.11.05.005


Web Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. https://www.eurchembull.com/?mno=45341 [Access: September 25, 2022]. doi:10.31838/ecb/2022.11.05.005


AMA (American Medical Association) Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB. 2022; 11(5): 31-37. doi:10.31838/ecb/2022.11.05.005



Vancouver/ICMJE Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB. (2022), [cited September 25, 2022]; 11(5): 31-37. doi:10.31838/ecb/2022.11.05.005



Harvard Style

kzar, h. H., , . Z. H. K. & Al-Charak, . A. G. (2022) Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB, 11 (5), 31-37. doi:10.31838/ecb/2022.11.05.005



Turabian Style

kzar, hamzah H, Zahraa H Kadhim, and Areej GH Al-Charak. 2022. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. European Chemical Bulletin, 11 (5), 31-37. doi:10.31838/ecb/2022.11.05.005



Chicago Style

kzar, hamzah H, Zahraa H Kadhim, and Areej GH Al-Charak. "Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats." European Chemical Bulletin 11 (2022), 31-37. doi:10.31838/ecb/2022.11.05.005



MLA (The Modern Language Association) Style

kzar, hamzah H, Zahraa H Kadhim, and Areej GH Al-Charak. "Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats." European Chemical Bulletin 11.5 (2022), 31-37. Print. doi:10.31838/ecb/2022.11.05.005



APA (American Psychological Association) Style

kzar, h. H., , . Z. H. K. & Al-Charak, . A. G. (2022) Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. European Chemical Bulletin, 11 (5), 31-37. doi:10.31838/ecb/2022.11.05.005