Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats

hamzah H kzar; Zahraa H Kadhim; Areej GH Al-Charak

doi:10.31838/ecb/2022.11.05.005

2022, Vol: 11, Issue: 6

11/6Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Research Article

ECB. 2022; 11(5): 31-37

doi: 10.31838/ecb/2022.11.05.005

Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats

hamzah H kzar, Zahraa H Kadhim, Areej GH Al-Charak.

Abstract
Abstract
In this study, we examined the berberine-chitosan nanoparticles (BCNP) action as a natural polymer used to enhance liver and kidney damage induced by phenylhydrazine in male rats. Healthy 20 male Sprague-Dawley rats weighed 150 - 200 g were used in this study and the animals were randomly divided into four groups, G1: (CON), G2: chitosan (CHS), G3: berberine (BER), and G4: berberine-chitosan NPs (BCNPs). Serum ALT, AST, TP, and TB for assessment of liver damage, and creatinine (CRI) and urea (UR) were measured to investigate kidney damage. The administration of experimental rats with BCNPs done by the current study BCNPs with the dose of 0.5 mg/Kg B.W. will be given protection from hepatotoxic and kidney damage action of phenylhydrazine. Liver sections revealed moderate improvement of the hepatic artery, portal vein, and bile duct and reorganization of hepatic cords. Kidney sections illustrated also moderate improvement of tubular necrosis. In conclusion, the usage of BCNPs as a natural polymer with moderated modifications has greatly improved the curative effect of pure BER and CHS to protect the liver and kidneys against toxicity induced by phenylhydrazine that may be by a reduction in lipid peroxidation and enhancement of the main markers of liver and kidney.

Key words: Liver and kidney damage, Berberine, Chitosan, drug delivery,

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by hamzah H kzar Articles by Zahraa H Kadhim Articles by Areej GH Al-Charak
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB. 2022; 11(5): 31-37. doi:10.31838/ecb/2022.11.05.005

Web Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. https://www.eurchembull.com/?mno=45341 [Access: September 25, 2022]. doi:10.31838/ecb/2022.11.05.005

AMA (American Medical Association) Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB. 2022; 11(5): 31-37. doi:10.31838/ecb/2022.11.05.005

Vancouver/ICMJE Style

kzar hH, ZHK, Al-Charak AG. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB. (2022), [cited September 25, 2022]; 11(5): 31-37. doi:10.31838/ecb/2022.11.05.005

Harvard Style

kzar, h. H., , . Z. H. K. & Al-Charak, . A. G. (2022) Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. ECB, 11 (5), 31-37. doi:10.31838/ecb/2022.11.05.005

Turabian Style

kzar, hamzah H, Zahraa H Kadhim, and Areej GH Al-Charak. 2022. Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. European Chemical Bulletin, 11 (5), 31-37. doi:10.31838/ecb/2022.11.05.005

Chicago Style

kzar, hamzah H, Zahraa H Kadhim, and Areej GH Al-Charak. "Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats." European Chemical Bulletin 11 (2022), 31-37. doi:10.31838/ecb/2022.11.05.005

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

kzar, h. H., , . Z. H. K. & Al-Charak, . A. G. (2022) Biochemical and Histological Study on Berberine-Chitosan Nanoparticles Effects on Improvement of the Induced Liver and kidney Damage in Male Rats. European Chemical Bulletin, 11 (5), 31-37. doi:10.31838/ecb/2022.11.05.005

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in European Chemical Bulletin are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright � 2022 European Chemical Bulletin All Rights Reserved. Subject to change without notice from or liability to European Chemical Bulletin. For best results, please use Internet Explorer or Google Chrome	Contact Information European Chemical Bulletin Budapest, Near Széchenyi István tér, 1051 Hungary Email : editor@eurchembull.com

Contact Information

How to cite this article