E-ISSN 2063-5346
 

Original Article 


FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo.

Abstract
Nebivolol hydrochloride (NBH) chitosan-PLGA loaded nanoparticles obtained using the nanoprecipitation/solvent
displacement process in the present study, characterization by P-XRD, DSC, SEM, and FTIR analytical techniques. During the invitro drug release, ex-vivo permeation studies. The nanoparticles prepared to employ 150mg chitosan, 100mg PLGA, and 1:5 H2O:
CH2Cl2 incorporated with NBH showed a high drug entrapment of approximately 94%, with an average particle diameter of 180.32
nm and zeta potential of −30.40±0.12 mV. The nanoparticles exhibited a sustainable drug release when studied for 60 minutes. The
nanoparticles mentioned above were later formulated into a nanogel with the help of Carbopol 934 for transdermal application and
subjected to ex-vivo permeation studies for 12 hours on excised rat’s skin. The optimized formulation subjected to studies in rats
showed a considerable enhancement in bioavailability (3 folds) compared with the NBH oral suspension.

Key words: Nebivolol hydrochloride, Nanoparticles, Carbopol 934, Nanogel, Bioavailability


 
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Pubmed Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. ECB. 2022; 11(10): 72-81. doi:10.31838/ecb/2022.11.10.010


Web Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. https://www.eurchembull.com/?mno=129998 [Access: November 29, 2022]. doi:10.31838/ecb/2022.11.10.010


AMA (American Medical Association) Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. ECB. 2022; 11(10): 72-81. doi:10.31838/ecb/2022.11.10.010



Vancouver/ICMJE Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. ECB. (2022), [cited November 29, 2022]; 11(10): 72-81. doi:10.31838/ecb/2022.11.10.010



Harvard Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo (2022) FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. ECB, 11 (10), 72-81. doi:10.31838/ecb/2022.11.10.010



Turabian Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. 2022. FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. European Chemical Bulletin, 11 (10), 72-81. doi:10.31838/ecb/2022.11.10.010



Chicago Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. "FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY." European Chemical Bulletin 11 (2022), 72-81. doi:10.31838/ecb/2022.11.10.010



MLA (The Modern Language Association) Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo. "FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY." European Chemical Bulletin 11.10 (2022), 72-81. Print. doi:10.31838/ecb/2022.11.10.010



APA (American Psychological Association) Style

Parameshwar Kondapuram, Dr. Suvendu Kumar Sahoo (2022) FORMULATION AND DEVELOPMENT OF NEBIVOLOL HYDROCHLORIDE LOADED CHITOSAN-PLGA BASED NANOGEL: EX VIVO PERMEATION AND IN VIVO PHARMACOKINETIC STUDY. European Chemical Bulletin, 11 (10), 72-81. doi:10.31838/ecb/2022.11.10.010