E-ISSN 2063-5346
 

Original Article 


SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY

Mugdivari Sangeetha, R.Gandhimathi.

Abstract
In our study we have a tendency to synthesized schiff’ base of bactericide drug sulphanilamide on treating with
aromatic aldehydes like p-diethyl amino benzyldehyde and p-dimethyl amino benzyldehyde. The synthesized schiff’s bases
were regenerate to its ion Schiff bases by treating with methyl group halide. The ion Schiff bases were regenerate to metal
complexes by treating with metals like CuCl2, ZnCl2 and CdCl2. All the synthesized compounds were characterised by
Elemental analysis, IR and 1H proton magnetic resonance. Docking study was performed to know the interaction of binding
sites with protein receptor using MAO-B enzymes (PDB ID: 2BK5) and COX-2 enzyme (PDB ID: 5IKR) by Virtual
Screening software for Computational Drug Discovery. Synthesized metal complexes were evaluated for antibacterial, anti
inflammatory and antidepressant activity. Copper metal complexes showed potent antibacterial and anti-inflammatory
activity. Significant anti-depressant activity was shown for 1A2 and 1B2 zinc metal complexes.

Key words: Sulphanilamide, antibacterial, anti-inflammatory, antidepressant activity


 
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Pubmed Style

Mugdivari Sangeetha, R.Gandhimathi. SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. ECB. 2022; 11(6): 74-81. doi:10.31838/ecb/2022.11.06.011


Web Style

Mugdivari Sangeetha, R.Gandhimathi. SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. https://www.eurchembull.com/?mno=112295 [Access: November 29, 2022]. doi:10.31838/ecb/2022.11.06.011


AMA (American Medical Association) Style

Mugdivari Sangeetha, R.Gandhimathi. SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. ECB. 2022; 11(6): 74-81. doi:10.31838/ecb/2022.11.06.011



Vancouver/ICMJE Style

Mugdivari Sangeetha, R.Gandhimathi. SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. ECB. (2022), [cited November 29, 2022]; 11(6): 74-81. doi:10.31838/ecb/2022.11.06.011



Harvard Style

Mugdivari Sangeetha, R.Gandhimathi (2022) SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. ECB, 11 (6), 74-81. doi:10.31838/ecb/2022.11.06.011



Turabian Style

Mugdivari Sangeetha, R.Gandhimathi. 2022. SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. European Chemical Bulletin, 11 (6), 74-81. doi:10.31838/ecb/2022.11.06.011



Chicago Style

Mugdivari Sangeetha, R.Gandhimathi. "SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY." European Chemical Bulletin 11 (2022), 74-81. doi:10.31838/ecb/2022.11.06.011



MLA (The Modern Language Association) Style

Mugdivari Sangeetha, R.Gandhimathi. "SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY." European Chemical Bulletin 11.6 (2022), 74-81. Print. doi:10.31838/ecb/2022.11.06.011



APA (American Psychological Association) Style

Mugdivari Sangeetha, R.Gandhimathi (2022) SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING OF SULPHANILAMIDE SCHIFF BASE METAL COMPLEXES AND ITS ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI DEPRESSANT ACTIVITY. European Chemical Bulletin, 11 (6), 74-81. doi:10.31838/ecb/2022.11.06.011