E-ISSN 2063-5346
 

Original Article 


HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen.

Abstract
Nephrotoxicity is regarded as one of the most important limitations of gentamicin used, in which it appears in 10–25%
of patients treated with gentamicin therapeutic doses, beside gentamicin nephrotoxicity has been considered to result widely from
tubular type damage of the kidney, therefore, this study performed on ten animals were divided into two groups equally; the animals
of the first group inject gentamicin (100mg / KG BW for ten days twice daily, then the treated animal was euthanized on the day
11th of the experiment and samples from internal organs were obtained for histopathological examination; the histopathological
analysis of the treated animals showed that In kidney ; there is area of dilated and vacuolated cortical tubules and increased
cellularity of glomeruli with prominent mesangial cells ,while in the livers were had early septal and per portal fibrosis, and
centrilobular enlargement of hepatocytes; In the thyroid gland there is the presence of micro follicles, also the follicles characterized
by large cells and small lumen, some with proliferation; in testis; there are some seminiferous tubules with vacuolation of
spermatogonea and reduced spermatogenesis, as well as there is a papillary projection in the epithelial lining of the epididymis, in
addition, there is suppression of spermatogenesis and presence of spermatids in the center of the lumen; in the spleen; the red pulp
is rich in cellularity with some pigment with prominent trabeculae and hemosiderin pigment; there are atrophic lymphoid follicles
of white pulp; while in the lungs there are dilated alveoli with an area of cystic alveoli suggesting emphysema. In conclusion,
gentamicin can cause harmful pathological changes in the vital organs of donkeys based on its therapeutic doses.

Key words: Histopathological, gentamicin, acute toxicity, equidae.


 
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How to Cite this Article
Pubmed Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. ECB. 2022; 11(6): 50-55. doi:10.31838/ecb/2022.11.06.007


Web Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. https://www.eurchembull.com/?mno=109756 [Access: November 29, 2022]. doi:10.31838/ecb/2022.11.06.007


AMA (American Medical Association) Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. ECB. 2022; 11(6): 50-55. doi:10.31838/ecb/2022.11.06.007



Vancouver/ICMJE Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. ECB. (2022), [cited November 29, 2022]; 11(6): 50-55. doi:10.31838/ecb/2022.11.06.007



Harvard Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen (2022) HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. ECB, 11 (6), 50-55. doi:10.31838/ecb/2022.11.06.007



Turabian Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. 2022. HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. European Chemical Bulletin, 11 (6), 50-55. doi:10.31838/ecb/2022.11.06.007



Chicago Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. "HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE." European Chemical Bulletin 11 (2022), 50-55. doi:10.31838/ecb/2022.11.06.007



MLA (The Modern Language Association) Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen. "HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE." European Chemical Bulletin 11.6 (2022), 50-55. Print. doi:10.31838/ecb/2022.11.06.007



APA (American Psychological Association) Style

Aseel Kamil Hameed, Jihad Abdulameer Ahmed, Rahman Kadhum Muhsen (2022) HISTOPATHOLOGICAL INVESTIGATION OF GENTAMICIN ACUTE TOXICITY IN EQUIDAE. European Chemical Bulletin, 11 (6), 50-55. doi:10.31838/ecb/2022.11.06.007