E-ISSN 2063-5346
 

Original Article 


PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto.

Abstract
Background: Optimization is part of the formulation process used in the manufacturing of pharmaceutical preparations
to obtain good and quality result, such as determining the number of drug substances. Aims of this study to determine the
optimum hydrogel in the extract combination of pinang yaki (Areca vestiary Giseke) fruit stalk, gedi (Abelmoschus manihot
Linn.) leaf, and goroho (Musa-Eumusa-AAB) banana fruit peels based on pH, spreadibility, and anti-microorganism. Extraction
using ethanol was carried out on Pinang yaki (Areca vestiary Giseke) fruit stalk, gedi (Abelmoschus manihot Linn.) leaf, and
goroho (Musa-Eumusa-AAB) banana fruit peels. The extracts were used for hydrogel preparation. Aim: Formula optimization of
the hydrogel based on the weight of each extract was carried out using the simplex lattice design (SLD) program. Material and
method: The optimization process was carried out on 13 cycles formulas with different extract compositions. The responses
tested in the process were pH value, spreadability, antibacterial activity against Staphylococcus aureus, and Escherichia coli, and
antifungal activity against Candida albicans. Results: The optimal concentration proposed by the SLD program was 0.50 g of
pinang yaki (Areca vestiary Giseke) fruit stalk extract, 0.42 g of gedi (Abelmoschus manihot Linn.) leaf extract, and 1.08 g of
goroho (Musa-Eumusa-AAB) banana fruit peels extract. The desirability value for the optimum formula is 0.706, which means
that the response variable of the optimization process is getting closer to the predetermined target value. Conclusion: The values
of pH, spreadability, inhibition of S. aureus, E. coli, and C. albicans in the hydrogel formula predicted by the SLD program were:
6.44, 5.66 cm, 2.06 cm, 1.67 cm, and 1.59 cm.

Key words: Formula optimization, simplex lattice design, pinang Yaki (Areca vestiary Giseke), gedi (Abelmoschus manihot Linn.), goroho banana (Musa-Eumusa-AAB).


 
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How to Cite this Article
Pubmed Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. ECB. 2022; 11(6): 20-32. doi:10.31838/ecb/2022.11.06.004


Web Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. https://www.eurchembull.com/?mno=109353 [Access: November 29, 2022]. doi:10.31838/ecb/2022.11.06.004


AMA (American Medical Association) Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. ECB. 2022; 11(6): 20-32. doi:10.31838/ecb/2022.11.06.004



Vancouver/ICMJE Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. ECB. (2022), [cited November 29, 2022]; 11(6): 20-32. doi:10.31838/ecb/2022.11.06.004



Harvard Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto (2022) PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. ECB, 11 (6), 20-32. doi:10.31838/ecb/2022.11.06.004



Turabian Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. 2022. PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. European Chemical Bulletin, 11 (6), 20-32. doi:10.31838/ecb/2022.11.06.004



Chicago Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. "PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL." European Chemical Bulletin 11 (2022), 20-32. doi:10.31838/ecb/2022.11.06.004



MLA (The Modern Language Association) Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto. "PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL." European Chemical Bulletin 11.6 (2022), 20-32. Print. doi:10.31838/ecb/2022.11.06.004



APA (American Psychological Association) Style

Hosea Jaya Edy, Widya Astuty Lolo, Weny Indayany Wiyono, Edy Parwanto (2022) PREDICTION OF THE SIMPLEX LATTICE DESIGN PROGRAM ON THE HYDROGEL FORMULA IN THE COMBINATION EXTRACT OF PINANG YAKI (ARECA VESTIARY GISEKE) FRUIT STALK, GEDI (ABELMOSCHUS MANIHOT LINN.) LEAF, AND GOROHO (MUSA-EUMUSA-AAB) BANANA PEEL. European Chemical Bulletin, 11 (6), 20-32. doi:10.31838/ecb/2022.11.06.004