EFFECT OF COBALT-EDTA ON IRON CONTENT IN SPLEEN AND LIVER OF IMMATURE MICE

Yordanka Gluhcheva, Ekaterina Pavlova, Vasil Atanasov, Juliana Ivanova, Ivelin Vladov, Sonja Ganeva, Mariana Mitewa

Abstract


Cobalt (Co) is an essential trace element and its accumulation affects the concentrations of other elements. Co(II) is shown to compete with iron (Fe) for the transferrin receptor and to form a stable complex with hemoglobin thus affecting hematopoiesis. There are lack of data regarding the effect of chronic exposure to Co compounds and Fe content in spleen and liver of mice. The study investigates the effect of long-term treatment with cobalt-EDTA (Co-EDTA) on iron content in the spleen and liver of immature mice. Pregnant ICR mice were subjected to chronic treatment with daily dose of 75 mg/kg Co-EDTA which continued until d25 of the newborn pups. Results show accumulation of Co(II) in the organs of treated mice compared to age-matched controls. Fe content in the spleen and liver was affected as well. Significantly increased concentrations of Fe ions were measured in the livers of treated mice. The changes could explain impaired hematopoiesis and immune responses of exposed to Co(II) immature mice.

Full Text:

PDF


DOI: http://dx.doi.org/10.17628/ecb.2012.1.442-444

Refbacks

  • There are currently no refbacks.


 

*********************** European Chemical Bulletin *******************