CERRIC AMMONIUM NITRATE (CAN) CATALYSED SYNTHESIS OF PYRANO[2,3-d]PYRIMIDINE-2,4,7-TRIONES IN AQUEOUS MEDIUM UNDER SONICATION VIA ONE-POT THREE COMPONENT REACTON

Anshu Dandia, Shyam L. Gupta, Sumit Bhaskaran

Abstract


A green, environmentally benign, facile and efficient one-pot three-component reaction of benzaldehyde, barbituric acid and meldrum acid for the synthesis of 5-phenyl-5,6-dihydro-1H-pyrano[2,3-d]pyrimidine-2,4,7(3H)-trione derivatives using cerric ammonium nitrate (CAN) as a catalyst in aqueous medium under ultrasonic irradiation is described. 1,3-dimethyl barbituric acid gives slightly lower yield as compared to barbituric acid and takes longer time to complete the reaction. Excellent yields, no need of base, and simple workup procedure are the prominent features of this protocol.


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DOI: http://dx.doi.org/10.17628/ecb.2013.2.836-841

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