CRUSH SYNDROME INFLUENCE ON THE ULTRASTRUCTURE OF HEPATOCYTES AND NEURONES

G. R. Karapetyan, N. S. Kukurtchyan, G. A. Kevorkian

Abstract


Today one of the most actual questions is the nature of the toxic damages of organs. CS as a specific type of traumatic damages lead to the whole complex of ultrastructural pathology.

The aim of this study was to find the dynamic of ultrastructural changes of liver at CS and the role of PRP-1 (proline rich peptide) as a protector.

The experimental model of Crush syndrome (CS) was induced by compression of femoral soft tissues using a special press with a compression force 100 kg/kg body weight for 2 hr. Further investigations were performed by use of method of transmission electron microscopy.

Our investigation demonstrated that Mch of brain are more subject to changes at 2 hr of compression than liver Mch, but one time administration of the PRP-1 in a dosage of 10 mcg/100g of the animal weight before decompression period prevent the development of the destructive changes of the hepatocytes of the liver and neurons of the rat cortex (injection of PRP on the background of CS prevent progress of ultrastructural changes typical at 4hr of decompression, and leads to Mch fission).

 


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DOI: http://dx.doi.org/10.17628/ecb.2013.2.726-731

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